How is (3S,4aS,8aS)-N-(2-Methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide (CAS: 136465-81-1) typically synthesized?

(3S,4aS,8aS)-N-(2-Methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide can be synthesized through a multi-step process involving the reduction of an isoquinoline derivative followed by alkylation and amidation reactions. The key steps include the use of a reducing agent like lithium aluminum hydride (LAH) and a protecting group like benzyl ether, followed by deprotection and amidation to form the final product. The yield and selectivity can be enhanced by careful control of reaction conditions and choice of catalysts.