Compound Q&A
How is Nilotinib hydrochloride monohydrate (CAS: 923288-90-8) typically synthesized?
Answer
Nilotinib hydrochloride monohydrate is synthesized through a multi-step process involving condensation reactions, hydrogenation, and hydrochloric acid treatment. The key steps include the conversion of an intermediate to the target compound, followed by hydrochloridation and crystallization. The process typically yields 85-90% purity with high selectivity.
About
CAS No
923288-90-8
English Name
Nilotinib hydrochloride monohydrate
Molecular Formula
C28H25ClF3N7O2
Molecular Weight
584 g/mol
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.O.Cl
InChIKey
YCBPQSYLYYBPDW-UHFFFAOYSA-N
Last Updated: 2025-09-09 19:18
