How is (2R)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-(2-naphthyl)propanoic acid (CAS: 76985-10-9) typically synthesized?

This compound can be synthesized via the carboxylation of 2-naphthylalanine methyl ester using sodium hydride as a base and carbon dioxide as the CO2 source. The synthetic method involves the coupling of amino acid derivatives and naphthalene, with a yield of up to 75%. The reaction is typically carried out under anhydrous conditions and at elevated temperatures.