Compound Q&A
How is Pemetrexed disodium hemipenta hydrate (CAS: 357166-30-4) typically synthesized?
Answer
Pemetrexed disodium hemipenta hydrate is synthesized via a multi-step process involving the synthesis of pemetrexed monophosphate and subsequent conversion to the hemipenta hydrate form. Key steps include the condensation of L-threonine with other reagents, followed by sodium salt formation and hydration. The reaction is catalyzed by various organic acids and typically yields up to 90% purity.
About
CAS No
357166-30-4
English Name
Pemetrexed disodium hemipenta hydrate
Molecular Formula
C40H48N10Na4O17
Molecular Weight
1032.83 g/mol
EINECS
814-356-7
SMILES
[O-]C(=O)CCC(C(=O)[O-])NC(=O)c1ccc(cc1)CCc1c[nH]c2c1c(=O)nc([nH]2)N.[O-]C(=O)CCC(C(=O)[O-])NC(=O)c1ccc(cc1)CCc1c[nH]c2c1c(=O)nc([nH]2)N.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]
InChIKey
ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
Last Updated: 2025-09-09 08:06
