Pemetrexed disodium hemipenta hydrate(CAS: 357166-30-4)

Pemetrexed disodium hemipenta hydrate is a crystalline compound with a molecular weight of approximately 719.48 g/mol. It has high solubility in water and moderate solubility in ethanol. The compound exhibits good stability under normal conditions but is sensitive to strong acids and bases. It is typically used in pharmaceutical applications.

Pemetrexed disodium hemipenta hydrate is synthesized via a multi-step process involving the synthesis of pemetrexed monophosphate and subsequent conversion to the hemipenta hydrate form. Key steps include the condensation of L-threonine with other reagents, followed by sodium salt formation and hydration. The reaction is catalyzed by various organic acids and typically yields up to 90% purity.

Pemetrexed disodium hemipenta hydrate is primarily used in the pharmaceutical industry, particularly in the development and production of antifolate chemotherapy drugs. It is also used in research applications related to cancer treatment and cell biology.

When handling Pemetrexed disodium hemipenta hydrate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be performed in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.