Compound Q&A

How is (4S)-4-Hydroxy-L-proline (CAS: 618-27-9) typically synthesized?

Answer

(4S)-4-Hydroxy-L-proline
(4S)-4-Hydroxy-L-proline can be synthesized via the hydroxylation of L-proline using a hydrogen peroxide/ferrous sulfate system. The reaction yields a 90% pure product with good selectivity and a high yield of 85%.

About

CAS No 618-27-9
English Name (4S)-4-Hydroxy-L-proline
Molecular Formula C5H9NO3
Molecular Weight 131.13 g/mol
SMILES C1C(CNC1C(=O)O)O
InChIKey PMMYEEVYMWASQN-IMJSIDKUSA-N
Last Updated: 2025-09-08 00:42

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