Compound Q&A
How is Saxagliptin hydrate (CAS: 945667-22-1) typically synthesized?
Answer
Saxagliptin hydrate is synthesized via a multi-step process involving key steps such as the reduction of an aldehyde, followed by protection of the hydroxyl group, cyclization, and subsequent deprotection. The final step involves the formation of the hydrate form, which is achieved by crystallization from water. The overall yield is around 70-75%.
About
CAS No
945667-22-1
English Name
Saxagliptin hydrate
Molecular Formula
C18H27N3O3
Molecular Weight
17.03 g/mol
SMILES
C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.O
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Last Updated: 2025-09-08 00:42
