Saxagliptin hydrate(CAS: 945667-22-1)

Saxagliptin hydrate is a white to off-white crystalline powder. It has a molecular weight of approximately 464.6 g/mol and a solubility of about 47 mg/mL in water. It is moderately reactive with strong acids and bases. The compound is stable under normal storage conditions but should be protected from moisture and light.

Saxagliptin hydrate is synthesized via a multi-step process involving key steps such as the reduction of an aldehyde, followed by protection of the hydroxyl group, cyclization, and subsequent deprotection. The final step involves the formation of the hydrate form, which is achieved by crystallization from water. The overall yield is around 70-75%.

Saxagliptin hydrate is primarily used in the pharmaceutical industry for the production of the diabetes drug Tradjenta. It is also of interest in academia and research for studying its effects on glucose regulation and for potential use in other pharmacological applications.

When handling Saxagliptin hydrate, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a cool, dry place away from direct sunlight. If a spill occurs, it should be cleaned up with caution using appropriate spill kits and disposing of the waste properly. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.