Compound Q&A

How is 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (CAS: 122368-54-1) typically synthesized?

Answer

2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is typically synthesized through a multistep process involving the coupling of 4-chloroaniline with 4-piperidinol, followed by a functional group transformation using a piperidine derivative. The synthesis involves the use of catalysts such as triphenylphosphine and an appropriate coupling reagent. The overall yield is moderate, and the method provides good selectivity for the target compound.

About

English Name 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine
Molecular Formula C17H19ClN2O
Molecular Weight 302.81 g/mol
SMILES C1CNCCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3
InChIKey OTZYADIPHOGUDN-UHFFFAOYSA-N
Last Updated: 2025-09-08 00:42

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