Compound Q&A
How is Navitoclax (CAS: 923564-51-6) typically synthesized?
Answer
Navitoclax is typically synthesized through a multi-step organic synthesis route. The key steps involve the protection of the hydroxyl groups, formation of the amide bond, and subsequent deprotection. Common catalysts used include TBTU and HATU, and the synthetic method is highly selective, yielding around 80-85% purity. The process is optimized for efficiency and scalability.
About
CAS No
923564-51-6
English Name
Navitoclax
Molecular Formula
C47H55ClF3N5O6S3
Molecular Weight
974.6339999999994 g/mol
SMILES
CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
InChIKey
JLYAXFNOILIKPP-KXQOOQHDSA-N
Last Updated: 2025-09-05 20:45
