How is 2'-O-Methylcytidine (CAS: 2140-72-9) typically synthesized?

2'-O-Methylcytidine (CAS: 2140-72-9) is synthesized through a multi-step process involving alkylation of cytidine with methanol in the presence of a base like sodium hydride. Commonly used catalysts include palladium on carbon, and the reaction is typically carried out under mild conditions. The product is then purified by recrystallization or column chromatography. The yield can range from 50% to 70%, depending on the optimization of the reaction conditions.