Is Propylene Glycol (CAS: 57-55-6) safe?

Propylene glycol (CAS: 57-55-6) is generally recognized as safe (GRAS) by the FDA for use in food and pharmaceutical products. However, proper handling is essential to ensure safety. While it has low toxicity, prolonged skin contact may cause irritation, and inhalation of vapors can lead to respiratory discomfort. Safety standards, such as those outlined by OSHA and the EPA, emphasize the need for protective measures like gloves, goggles, and ventilation when working with larger quantities. In industrial settings, adherence to safety data sheets (SDS) is crucial to identify potential hazards and mitigation strategies. The compound is considered non-flammable and has a low risk of combustion, but it should be stored away from heat sources. Its safety profile makes it a preferred alternative to more hazardous substances like ethylene glycol in many applications.