Bimatoprost isopropyl ester;Isopropyl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-5-heptenoate(CAS: 130209-76-6)

Bimatoprost isopropyl ester (17-phenyl trinor PGF₂α isopropyl ester) is a synthetic prostaglandin F‑series analog. It is the isopropyl ester prodrug of bimatoprost, and its active form—the free acid 17‑phenyl trinor PGF₂α—is a potent FP receptor agonist. It should be noted that its C‑15 stereoisomer, 15(R)‑bimatoprost isopropyl ester, is a related isomer and potential impurity of latanoprost. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.