(5-NITROPYRIDIN-2-YL)ACETONITRILE(CAS: 123846-66-2)

(5-Nitro-2-pyridinyl)acetonitrile is a crystalline solid at room temperature. Its molecular weight is approximately 184.12 g/mol. It is sparingly soluble in water but soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly with nucleophiles and reducing agents. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

(5-Nitro-2-pyridinyl)acetonitrile is commonly synthesized via the nitration of 2-pyridinylacetonitrile using concentrated nitric acid as the oxidizing agent. The reaction is carried out under reflux conditions, and the product is typically obtained with good selectivity and yield. Proper handling of nitric acid and other reagents is necessary to ensure safety and efficiency.

(5-Nitro-2-pyridinyl)acetonitrile is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It also finds applications in the preparation of sensors and as a building block in the synthesis of materials for semiconductors. Its use in polymers is limited but it can be used in specific applications requiring specific chemical functionalities.

When handling (5-Nitro-2-pyridinyl)acetonitrile, it is important to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. The substance should be used in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. In case of exposure, seek medical attention and refer to the Material Safety Data Sheet (MSDS) for further instructions. This compound is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight and sources of ignition.