TRANS-4-METHYLTETRAHYDROFURAN-3-OL(CAS: 387357-58-6)

Rac-(3R,4S)-4-methyloxolan-3-ol, trans is a colorless crystalline solid with a molecular weight of approximately 114.16 g/mol. It has a melting point of around 62-64°C and a boiling point of about 150°C. This compound is slightly soluble in water and more soluble in organic solvents. It is chemically stable but can react with strong oxidizing agents. It is also an alcohol and may exhibit basic properties due to its hydroxyl group.

Rac-(3R,4S)-4-methyloxolan-3-ol, trans can be synthesized through the kinetic resolution of 1,4-dimethyl-2,3-epoxybutane using chiral auxiliaries. Common methods include the use of chiral metal complexes as catalysts, which provide good yields and high enantiomeric excess. The reaction typically involves the selective epimerization of one stereocenter, leading to the formation of the desired trans isomer.

Rac-(3R,4S)-4-methyloxolan-3-ol, trans is primarily used in the pharmaceutical industry for the synthesis of chiral intermediates and as a chiral auxiliar. It is also utilized in polymer chemistry for the modification of polymer properties, in the production of sensors for detecting certain chemicals, and in semiconductor manufacturing as a precursor for chiral compounds.

When handling rac-(3R,4S)-4-methyloxolan-3-ol, trans (CAS: 387357-58-6), it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Fume hoods should be used during synthesis and handling to minimize exposure. In case of a spill, immediately contain the spill using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal.