(S)-1-(4-METHYLPHENYL)ETHANOL(CAS: 51154-54-2)

(S)-1-(4-Methylphenyl)ethanol has a melting point of 48-49°C and a boiling point of 110-112°C. It is a colorless to slightly yellow liquid with a molecular weight of 144.22 g/mol. Its solubility is 0.47 g/100 mL water. It is reactive towards acids and bases.

(S)-1-(4-Methylphenyl)ethanol is typically synthesized via kinetic resolution of racemic 1-(4-methylphenyl)ethanol using chiral auxiliary or through kinetic resolution with a kinetic resolution agent. The yield is usually around 85-90%, with high enantiomeric excess (EE) of >95%. A catalyst like cinchona alkaloid or other chiral organocatalysts can be used for enhanced selectivity.

(S)-1-(4-Methylphenyl)ethanol is used in the pharmaceutical industry for the synthesis of chiral compounds, in the polymer industry as a monomer, and in the sensor industry for detecting certain chemicals. It is also applied in the semiconductor industry for etching processes.

Handling (S)-1-(4-Methylphenyl)ethanol requires the use of personal protective equipment (PPE) such as gloves and goggles. It should be conducted in a fume hood to avoid inhalation. Spills should be cleaned up with absorbent materials and care should be taken to follow safety data sheet (SDS) guidelines. Avoid contact with eyes and skin, and ensure proper ventilation.