6-((2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)AMINO)-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE(CAS: 575484-83-2)

6-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one has a crystalline form with a molecular weight of approximately 403.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and DMF. This compound is relatively stable under acidic and neutral conditions but can react with strong bases. It is used in pharmaceutical applications.

6-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one is synthesized through a multi-step process involving the coupling of 2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one with 2-chloro-5-fluoro-4-pyrimidinamine. This reaction is typically carried out in the presence of a base and a suitable solvent. The yield is around 75-80% and the process is highly selective.

6-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one is primarily used in the pharmaceutical industry for the synthesis of drugs. It is also utilized in sensor applications and as a precursor in semiconductor manufacturing due to its electronic properties.

When handling 6-[(2-Chloro-5-fluoro-4-pyrimidinyl)amino]-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, it should be done in a well-ventilated area with the use of appropriate personal protective equipment (PPE) including gloves and eye protection. It should be stored in a closed container in a dry, cool, and well-ventilated area. In case of spill, it should be handled according to the safety data sheet (SDS) guidelines.