5'-O-DMT-N6-BENZOYL-2'-FLUORO-2'-DEOXYADENOSINE(CAS: 146954-77-0)

4-(Benzoylamino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-2-fluoro-beta-D-xylofuranosyl}-2(1H)-pyrimidinone is a crystalline compound with a molecular weight of approximately 1035.4 g/mol. It has low solubility in water but is soluble in organic solvents such as DMSO and acetonitrile. The compound is relatively stable under normal conditions but reacts with strong bases to form the corresponding amine. It exhibits good reactivity towards nucleophilic substitution and is an important intermediate in the synthesis of bioactive compounds.

The compound is synthesized through a multi-step process involving the protection of the sugar moiety, followed by the introduction of the benzoyl group, and the subsequent installation of the fluoro substituent. The reaction typically requires the use of protecting groups such as acetals and is catalyzed by conditions that ensure high selectivity. The overall yield of the compound can range from 30% to 70%, depending on the specific reaction conditions.

This compound is primarily used in the pharmaceutical industry as a key intermediate in the synthesis of drugs with anti-inflammatory and antiviral properties. It is also used in the polymer industry for the development of advanced materials with specific functional groups. Additionally, it has potential applications in the semiconductor industry for the fabrication of novel electronic materials.

When handling this compound, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Ensure that the work is conducted in a well-ventilated fume hood to minimize exposure to the compound. In the event of a spill, immediately clean up the area using appropriate absorbent materials and follow local safety protocols. Always consult the Safety Data Sheet (SDS) for detailed instructions on handling and disposal.