Compound Q&A
How is 4-(Benzoylamino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-2-fluoro-beta-D-xylofuranosyl}-2(1H)-pyrimidinone (CAS: 146954-77-0) typically synthesized?
Answer
![4-(Benzoylamino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-2-fluoro-beta-D-xylofuranosyl}-2(1H)-pyrimidinone](https://static.chemtradehub.com/structs/146/146954-77-0-093d.webp "4-(Benzoylamino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-2-fluoro-beta-D-xylofuranosyl}-2(1H)-pyrimidinone")
The compound is synthesized through a multi-step process involving the protection of the sugar moiety, followed by the introduction of the benzoyl group, and the subsequent installation of the fluoro substituent. The reaction typically requires the use of protecting groups such as acetals and is catalyzed by conditions that ensure high selectivity. The overall yield of the compound can range from 30% to 70%, depending on the specific reaction conditions.
About
CAS No
146954-77-0
English Name
4-(Benzoylamino)-1-{5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-2-fluoro-beta-D-xylofuranosyl}-2(1H)-pyrimidinone
Molecular Formula
C37H34FN3O7
Molecular Weight
651.68 g/mol
SMILES
COc1ccc(cc1)C(c1ccc(cc1)OC)(c1ccccc1)OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1ccc(nc1=O)NC(=O)c1ccccc1
InChIKey
RAIBEZUVTIPFOJ-NHASGABXSA-N
Last Updated: 2026-03-16 21:46
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