5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-arabinofuranosyl-2'-deoxyadenosine 3'-CE phosphoramidite(CAS: 329187-86-2)

N6-Benzoyl-9-(2'-deoxy-5’-O-DMT-2’-fluoro-b-D-arabinofuranosyl)adenine 3’-CE-phosphoramidite is a white to off-white crystalline solid with a molecular weight of approximately 588.4 g/mol. It has poor water solubility but good solubility in organic solvents like acetonitrile and DMF. It is reactive towards nucleophiles and can form phosphodiester bonds under appropriate conditions. This compound is often used in the synthesis of oligonucleotides and requires careful handling due to its reactivity.

N6-Benzoyl-9-(2'-deoxy-5’-O-DMT-2’-fluoro-b-D-arabinofuranosyl)adenine 3’-CE-phosphoramidite is synthesized through a multi-step process involving the protection of the sugar, installation of the fluorescent label (DMT), and the introduction of the phosphoramidite functionality. This process often involves organic solvents and requires precise control over reaction conditions to achieve high yields and selectivity.

N6-Benzoyl-9-(2'-deoxy-5’-O-DMT-2’-fluoro-b-D-arabinofuranosyl)adenine 3’-CE-phosphoramidite is primarily used in the pharmaceutical and biotechnology industries for the synthesis of oligonucleotides and fluorescent probes. It is also relevant in the development of sensors and materials science applications where specific nucleic acid functionalities are required.

When handling N6-Benzoyl-9-(2'-deoxy-5’-O-DMT-2’-fluoro-b-D-arabinofuranosyl)adenine 3’-CE-phosphoramidite, it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety glasses. Ensure that the work is conducted in a well-ventilated fume hood to minimize exposure to the compound. Spills should be cleaned up using appropriate organic solvents and the area should be washed down with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.