(1R)-4,7,7-TRIMETHYL-3-OXO-2-OXABICYCLO[2.2.1]HEPTANE-1-CARBOXYLIC ACID(CAS: 67111-66-4)

(1R,4R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid (CAS: 67111-66-4) is a white, crystalline solid with a molecular weight of approximately 218.34 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and ethanol. Chemically, it exhibits moderate reactivity, particularly in esterification and amidation reactions. It is stable under normal conditions but should be stored at room temperature, protected from moisture and light.

(1R,4R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid is commonly synthesized via a Wittig reaction followed by acidification. The synthesis involves the reaction of a suitable ketone with methylene tribromide in the presence of a phosphonium salt as a base. The product is then isolated and purified by recrystallization. The reaction typically yields a high purity product with good selectivity and moderate to high yield.

(1R,4R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid is primarily used in the pharmaceutical industry as a precursor in the synthesis of certain drugs. It also finds applications in the polymer industry, where it can be used in the synthesis of certain polymers with specific properties. Additionally, it is used in the production of sensors and in semiconductor manufacturing as a precursor in the formation of certain organic films.

When handling (1R,4R)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylic acid (CAS: 67111-66-4), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize inhalation exposure. If a spill occurs, it should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always consult the safety data sheet (SDS) for detailed handling and storage information.