1-(4-Fluoro-3-nitrophenyl)methanamine(CAS: 771581-73-8)

1-(4-Fluoro-3-nitrophenyl)methanamine (CAS: 771581-73-8) is a crystalline compound with a molecular weight of approximately 214.07 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound shows low reactivity under normal conditions but can be sensitive to oxidizing agents due to its nitro and fluoro substituents. It exhibits acidic behavior due to the nitro group.

1-(4-Fluoro-3-nitrophenyl)methanamine can be synthesized by coupling 4-fluoro-3-nitrobenzoic acid with methylamine. The synthesis involves esterification of the carboxylic acid group followed by nucleophilic substitution with methylamine. The reaction is typically conducted under mild conditions with appropriate solvents and catalysts to ensure high selectivity and yield. Common solvents include acetonitrile or dichloromethane.

1-(4-Fluoro-3-nitrophenyl)methanamine (CAS: 771581-73-8) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the development of advanced materials, and in the chemical sensor industry for detecting specific analytes. Its ability to form stable complexes with metal ions makes it useful in various analytical applications.

When handling 1-(4-Fluoro-3-nitrophenyl)methanamine (CAS: 771581-73-8), it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. The compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.