5-Chloro-N-{1-[4-(difluoromethoxy)phenyl]propyl}-6-methyl-4-pyrimidinamine(CAS: 130339-07-0)

The compound 5-Chloro-N-{1-[4-(difluoromethoxy)phenyl]propyl}-6-methyl-4-pyrimidinamine has a crystalline form and a molecular weight of approximately 411.2 g/mol. It has low water solubility but is soluble in organic solvents like DMSO. Chemically, it exhibits moderate reactivity, particularly towards nucleophilic substitution reactions.

This compound is synthesized via a multi-step process typically involving coupling reactions and protecting group strategies. Commonly, a trifunctional amine is reacted with a difluoromethoxy-substituted phenyl acetylene, followed by coupling with a methylated pyrimidine derivative. The synthesis often employs palladium catalysts and requires high selectivity and yield for efficient production.

5-Chloro-N-{1-[4-(difluoromethoxy)phenyl]propyl}-6-methyl-4-pyrimidinamine is primarily used in the pharmaceutical industry due to its biological activity. It may also find applications in the semiconductor industry for specific electronic properties and in the polymer industry for specialized polymers.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling this compound. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, immediately clean up with appropriate absorbent materials and ensure proper disposal. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.