4-bromo-6-fluoro-1H-indole(CAS: 885520-70-7)

4-bromo-6-fluoro-1H-indole (CAS: 885520-70-7) is a crystalline solid with a molecular weight of approximately 233.02 g/mol. It has low solubility in water but is soluble in organic solvents such as methanol and dichloromethane. The compound is relatively stable but can react with reducing agents. It is insoluble in water and has a melting point of around 205-208°C.

4-bromo-6-fluoro-1H-indole (CAS: 885520-70-7) is typically synthesized via a fluorination and bromination step starting from indole. Common methods include the use of trifluoroacetic anhydride for fluorination followed by bromination with N-bromosuccinimide in the presence of a photoinitiator. The yield is generally around 70-80%, and the reaction is highly selective.

4-bromo-6-fluoro-1H-indole (CAS: 885520-70-7) is used in the pharmaceutical industry for the synthesis of various bioactive compounds. It also has applications in the field of organic electronics, where it can be used as a precursor for semiconductors. Additionally, it may be utilized in the development of sensors and as a precursor in polymer synthesis.

When handling 4-bromo-6-fluoro-1H-indole (CAS: 885520-70-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated fume hood, and ensure proper spill containment and disposal methods are in place. Keep the compound away from reducing agents to prevent unwanted reactions. Refer to the safety data sheet (SDS) for detailed information on handling and storage.