1-[3-(1-Piperidinylmethyl)phenyl]methanamine(CAS: 91271-80-6)

1-[3-(1-Piperidinylmethyl)phenyl]methanamine (CAS: 91271-80-6) is a crystalline compound with a molecular weight of approximately 244.34 g/mol. It has a pKa of about 8.9 and can be soluble in organic solvents like methanol and ethanol. This compound is amphoteric, showing moderate reactivity in base-catalyzed reactions. It is stable under normal conditions but should be stored away from strong acids and bases to prevent degradation.

1-[3-(1-Piperidinylmethyl)phenyl]methanamine can be synthesized via a multi-step process involving amination of a substituted benzene, followed by reaction with piperidine. Commonly, a palladium-catalyzed cross-coupling reaction is used for the amination step. The overall yield can be around 60-70%, with good selectivity towards the desired product. Detailed procedures can be found in scientific literature and patents.

1-[3-(1-Piperidinylmethyl)phenyl]methanamine (CAS: 91271-80-6) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It also finds applications in the polymer industry as a monomer for producing certain types of plastics and resins. Additionally, it can be used in the development of sensors and as a building block in the synthesis of semiconductors.

When handling 1-[3-(1-Piperidinylmethyl)phenyl]methanamine (CAS: 91271-80-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be stored in a well-ventilated area, away from strong acids and bases. In case of a spill, it should be cleaned up immediately using appropriate absorbents. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.