2-Methylpropanoyl chloride(CAS: 79-30-1)

2-Methylpropanoyl chloride is a colorless or slightly yellow liquid with a molecular weight of 100.07 g/mol. It is slightly soluble in water and highly soluble in organic solvents. The compound is highly reactive, particularly with nucleophiles and bases, and can readily undergo hydrolysis to form 2-methylpropionic acid.

2-Methylpropanoyl chloride is typically synthesized by the chlorination of 2-methylpropanoyl alcohol. The reaction is usually carried out in the presence of a Lewis acid catalyst such as aluminum chloride to promote electrophilic substitution at the alcohol moiety.

2-Methylpropanoyl chloride finds application in the pharmaceutical industry for the synthesis of various intermediates and drugs, as well as in the polymer industry for the synthesis of certain polyesters and polymers. It is also used in the production of sensors and semiconductors.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 2-methylpropanoyl chloride. The substance should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and disposed of according to safety data sheet (SDS) guidelines.