5-Chloro-6-methoxynicotinic acid(CAS: 884494-85-3)

5-Chloro-6-methoxynicotinic acid is a white crystalline solid. Its molecular weight is approximately 223.65 g/mol. It is slightly soluble in water and soluble in ethanol. This compound is known for its high reactivity towards nucleophiles and its ability to undergo various substitution reactions.

5-Chloro-6-methoxynicotinic acid is typically synthesized through the methylation of nicotinic acid followed by chlorination. Commonly, nicotinic acid is treated with methyl iodide in the presence of a base like sodium hydroxide to form the methoxy derivative, which is then chlorinated using thionyl chloride. The overall yield is around 75-85%.

5-Chloro-6-methoxynicotinic acid is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the chemical industry for the production of various organic compounds and in research for developing new materials, such as sensors and semiconductors.

When handling 5-Chloro-6-methoxynicotinic acid, proper personal protective equipment (PPE) such as gloves and goggles should be worn. It should be stored in a cool, dry place away from direct sunlight. In case of spillage, the area should be cleaned with water and appropriate safety disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.