Mirodenafil dihydrochloride(CAS: 862189-96-6)

Mirodenafil dihydrochloride is a crystalline compound with a molecular weight of approximately 489.72 g/mol. It has a solubility of about 10 mg/mL in water. The compound exhibits moderate basicity and is stable under neutral and slightly acidic conditions. It is poorly soluble in common organic solvents like ethanol and acetone. Mirodenafil dihydrochloride reacts with strong acids to release the dihydrochloride salt and with bases to form the free base.

Mirodenafil dihydrochloride is synthesized through a multi-step process involving the protection of a hydroxyl group, followed by the formation of an amide bond, and subsequent deprotection and acidification to form the dihydrochloride salt. The synthesis involves the use of protecting agents like tert-butyldimethylsilyl chloride and deprotection using fluoride salts. The overall yield is around 70-75%, and the product is typically purified by recrystallization from ethanol.

Mirodenafil dihydrochloride (CAS: 862189-96-6) is primarily used in the pharmaceutical industry, specifically as an intermediate in the synthesis of its parent compound, mirabegron, which is an SNS receptor agonist used for treating overactive bladder. It is not extensively used in other industries like polymers, sensors, or semiconductors.

When handling Mirodenafil dihydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be performed in a well-ventilated environment or a fume hood due to its basic nature. Spills should be cleaned up using absorbent materials and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed instructions. Store the compound in a cool, dry place away from direct sunlight and sources of ignition.