(2S)-2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-2,3-dihydro-4H-chromen-4-one(CAS: 74628-43-6)

The compound (2S)-2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-2,3-dihydro-4H-chromen-4-one is a crystalline solid with a molecular weight of approximately 344.27 g/mol. It has limited water solubility and is soluble in organic solvents like ethanol and methanol. This compound shows moderate reactivity towards nucleophiles, particularly under basic conditions. It is stable under normal storage conditions but may degrade upon exposure to light and air.

This compound can be synthesized via a multistep reaction involving the protection of a phenolic hydroxyl group, followed by a condensation reaction to form the chromone skeleton. Common methods include the use of acetic anhydride for protection and the Birch reduction for the formation of the chromone. The reaction is typically conducted under anhydrous conditions with a yield of around 70-80%, and high selectivity towards the desired diastereoisomer.

This compound is primarily used in the pharmaceutical industry for the development of new drug candidates. It is also utilized in the polymer industry as a precursor for the synthesis of functional polymers with specific properties. Additionally, it has potential applications in the production of sensors and semiconductors due to its optical and electronic properties.

When handling (2S)-2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-2,3-dihydro-4H-chromen-4-one, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or with the use of a fume hood to minimize exposure. Spills should be cleaned up promptly with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and storage guidelines.