5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile(CAS: 799270-07-8)

5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is a solid compound with a crystalline form. Its molecular weight is approximately 267.04 g/mol. This compound has low water solubility but is soluble in organic solvents like DMF and DMSO. It is moderately reactive, showing some electrophilic character, and can undergo nucleophilic substitution reactions with a high degree of selectivity.

5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is synthesized through the bromination of 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile. The reaction is typically performed using N-bromosuccinimide (NBS) as the brominating agent in the presence of a suitable radical initiator like AIBN. The reaction yields a high percentage of the desired product with good selectivity.

5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the sensor industry for developing selective chemical sensors due to its unique reactivity. Additionally, it is utilized in the semiconductor industry for certain electronic applications.

When handling 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully, and appropriate safety data sheets (SDS) should be referenced for detailed handling and disposal instructions. Avoid contact with skin and eyes, and ensure proper disposal to prevent environmental contamination.