Methyl (4-aminophenyl)acetate hydrochloride (1:1)(CAS: 83528-16-9)

Methyl (4-aminophenyl)acetate hydrochloride (CAS: 83528-16-9) is a white crystalline solid with a molecular weight of approximately 229.77 g/mol. It has a pKa of around 2.3. The compound is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It is stable under normal conditions but should be stored in a dry place to prevent hydrolysis. Reactivity is moderate, and it is typically used in pharmaceutical and chemical applications due to its stability and reactivity.

Methyl (4-aminophenyl)acetate hydrochloride can be synthesized through a multi-step process. Initially, 4-aminophenol is esterified with acetic anhydride to form methyl (4-aminophenyl)acetate, which is then treated with hydrochloric acid. This process requires careful temperature control and can be optimized with the use of a catalyst like p-Toluenesulfonic acid. The yield is typically around 85-90%, and the final product is isolated by recrystallization.

Methyl (4-aminophenyl)acetate hydrochloride (CAS: 83528-16-9) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the production of electronic materials, specifically in the manufacturing of semiconductors due to its ability to form stable derivatives. Additionally, it can be used in the polymer industry as an intermediate for functional materials and in the development of new sensor technologies.

When handling Methyl (4-aminophenyl)acetate hydrochloride (CAS: 83528-16-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up immediately using appropriate absorbent materials. In case of skin contact, wash with plenty of water. For eye contact, flush with water for at least 15 minutes. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.