Ethyl 5-bromo-2-fluorobenzoate(CAS: 612835-53-7)

Ethyl 5-bromo-2-fluorobenzoate is a crystalline compound with a molecular weight of approximately 288.04 g/mol. It has a low solubility in water (0.1 g/L at 25°C) but is more soluble in organic solvents such as ethanol and acetone. It exhibits good reactivity in electrophilic aromatic substitution reactions due to the presence of the electron-withdrawing groups, bromine and fluorine.

Ethyl 5-bromo-2-fluorobenzoate is typically synthesized through the bromination and subsequent fluorination of ethyl benzoate. This involves the use of reagents such as N-bromosuccinimide (NBS) and N-fluorobencozide (NFBC) as electrophilic reagents. The reaction is conducted under mild conditions in an inert atmosphere to prevent side reactions.

Ethyl 5-bromo-2-fluorobenzoate is primarily used in the pharmaceutical and organic synthesis industries. It serves as a key intermediate in the synthesis of various biologically active compounds and fluorinated materials. Additionally, it is used in the development of new pharmaceuticals and as a building block in the production of functional polymers.

When handling Ethyl 5-bromo-2-fluorobenzoate, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be handled in a well-ventilated area or a fume hood due to potential inhalation risks. In the event of a spill, it should be cleaned up carefully using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.