HO-PEG16-OH(CAS: 6812-36-8)

HO-PEG16-OH is a polyethylene glycol derivative with a molecular weight of approximately 2,500 g/mol. It is a white, crystalline powder with good solubility in water and organic solvents. The compound is known for its hydrophilic nature and its ability to form stable associations with biomolecules. It is relatively stable under normal conditions but reacts with strong acids or bases to form carboxylic acids or salts.

HO-PEG16-OH is typically synthesized through the reaction of 16-oxido-2-oxo-1,2-ethanediol with ethylene oxide using catalytic amounts of sodium hydroxide. The reaction involves the gradual addition of ethylene oxide to the epoxide group of the starting material, followed by hydrolysis of the resulting ether intermediate to yield the final product.

HO-PEG16-OH finds applications in pharmaceuticals, where it serves as a drug delivery carrier or prodrug. It is also used in the polymer industry for synthesizing biodegradable polymers. Additionally, it is utilized in the development of biosensors, semiconductors, and as a stabilizer in cosmetics and personal care products.

When handling HO-PEG16-OH, it is recommended to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. In case of contact with eyes or skin, flush with copious amounts of water and seek medical advice. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information.