3-Chloro-2-fluoroisonicotinic acid(CAS: 741683-19-2)

3-Chloro-2-fluoroisonicotinic acid is a crystalline solid with a molecular weight of approximately 222.58 g/mol. It has a low solubility in water but is more soluble in organic solvents. This compound is relatively stable under normal conditions but can react with bases to form its salt form. It is used in the synthesis of pharmaceuticals and other organic compounds.

3-Chloro-2-fluoroisonicotinic acid can be synthesized through the chlorination and fluorination of nicotinic acid. Commonly, this involves reacting nicotinic acid with chlorine and fluorine gases under controlled conditions. The reaction is typically catalyzed by anhydrous aluminum chloride and yields a high purity product with good selectivity and yield.

3-Chloro-2-fluoroisonicotinic acid is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It also finds applications in the chemical industry for the production of intermediates and in research for developing new drug candidates. Its unique chemical structure makes it valuable for research in materials science and sensors.

When handling 3-Chloro-2-fluoroisonicotinic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be handled in a well-ventilated area or fume hood to prevent inhalation of fumes. Spills should be cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and storage information.