(4-Chloro-3-pyridinyl)boronic acid(CAS: 452972-10-0)

(4-Chloro-3-pyridinyl)boronic acid (CAS: 452972-10-0) is a crystalline solid with a molecular weight of approximately 225.03 g/mol. It has a solubility of 1.1 g/L in water and exhibits moderate reactivity in organic synthesis, particularly in Suzuki coupling reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

(4-Chloro-3-pyridinyl)boronic acid is typically synthesized via the chlorination of 3-pyridylboronic acid followed by deprotonation. Commonly, this involves the use of a base like sodium hydride in an inert solvent such as THF under anhydrous conditions. The yield is generally around 60-80%, and the reaction is highly selective for the chlorination of the pyridine ring.

(4-Chloro-3-pyridinyl)boronic acid finds use in the pharmaceutical and polymer industries. It is a key reagent in the synthesis of various bioactive compounds and functional polymers. Additionally, it is utilized in the production of sensors and semiconductors due to its specific reactivity and functional groups.

When handling (4-Chloro-3-pyridinyl)boronic acid (CAS: 452972-10-0), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Handle in a fume hood due to its potential volatility. In case of a spill, contain it with an absorbent material and dispose of it according to chemical waste protocols. Always refer to the Safety Data Sheet (SDS) for detailed safety information.