1-Fluoro-3-(trichloromethyl)benzene(CAS: 401-77-4)

1-Fluoro-3-(trichloromethyl)benzene (CAS: 401-77-4) is a crystalline solid with a molecular weight of approximately 246.48 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. This compound exhibits limited reactivity under normal conditions but can undergo substitution reactions under certain conditions. It is a potent chemical and should be handled with care.

1-Fluoro-3-(trichloromethyl)benzene (CAS: 401-77-4) is typically synthesized through the reaction of 3,5-dichlorobenzoyl chloride with fluorobenzene in the presence of a base such as sodium hydride. The reaction yields a high selectivity towards the desired product with good yield, although careful purification and handling are necessary.

1-Fluoro-3-(trichloromethyl)benzene (CAS: 401-77-4) finds application in various industries, including pharmaceuticals for intermediate synthesis, polymers as a monomer, and sensors for analytical purposes. It is also used in semiconductor manufacturing for specific purification processes.

When handling 1-Fluoro-3-(trichloromethyl)benzene (CAS: 401-77-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be carefully cleaned up using appropriate containment measures, and the substance should be stored in a cool, dry place away from strong oxidizers and acids. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.