Bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride(CAS: 27063-48-5)

Bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride is a colorless liquid with a molecular weight of approximately 156.12 g/mol. It is moderately soluble in water but miscible with common organic solvents like ethanol and acetone. This compound is highly reactive, particularly with nucleophiles, making it useful in various synthetic applications.

Bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride is synthesized through the reaction of 5-ene-2-pentanone with phosphorus oxychloride, followed by distillation to remove impurities. This method ensures high purity and yield, with the use of a Dean-Stark apparatus to remove water formed during the reaction.

Bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for modifying properties of polymers, and in the sensor industry for developing gas detection technologies. Its reactivity makes it valuable in semiconductor manufacturing processes as well.

When handling Bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be handled with caution, and the Material Safety Data Sheet (MSDS) should be consulted for detailed spill procedures.