4-Nitronicotinic acid 1-oxide(CAS: 1078-05-3)

4-Nitronicotinic acid 1-oxide (CAS: 1078-05-3) is a crystalline solid with a molecular weight of approximately 172.12 g/mol. It has a high solubility in water and a lower solubility in organic solvents. This compound is moderately reactive, exhibiting properties typical of carboxylic acid derivatives. It can undergo typical esterification and amidation reactions.

4-Nitronicotinic acid 1-oxide can be synthesized through the nitration of nicotinic acid followed by the formation of the oxime derivative. The nitration step typically requires concentrated nitric acid and sulfuric acid as a catalyst. The oxime formation is achieved by reacting the nitro compound with hydroxylamine under basic conditions.

4-Nitronicotinic acid 1-oxide (CAS: 1078-05-3) is primarily used in the pharmaceutical industry for the synthesis of drugs, particularly those involving derivatives of nicotinic acid. It also finds applications in polymer industry for modifying polymer properties and in the production of sensors and semiconductors for specific electronic applications.

When handling 4-Nitronicotinic acid 1-oxide (CAS: 1078-05-3), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that all handling takes place in a well-ventilated area or a fume hood. Proper storage should be in a cool, dry place away from sources of heat and ignition. In case of a spill, it should be cleaned up immediately using appropriate safety measures and materials. Refer to the Safety Data Sheet (SDS) for detailed safety instructions.