N-(3-Chlorophenyl)-2-pyridinecarboxamide(CAS: 61350-00-3)

N-(3-Chlorophenyl)-2-pyridinecarboxamide is a crystalline compound with a molecular weight of approximately 236.7 g/mol. It has a solubility of about 20 mg/mL in water and is slightly soluble in common organic solvents like dichloromethane and ethanol. It is relatively stable under normal conditions but can react with strong bases. It is typically used in the synthesis of other compounds and as a reagent in organic chemistry.

N-(3-Chlorophenyl)-2-pyridinecarboxamide can be synthesized through the coupling reaction of 3-chlorophenyl isocyanate with 2-pyridinecarboxamide. The synthesis typically involves heating the reactants in the presence of a catalyst such as 4-(dimethylamino)pyridine (DMAP) and a base like diisopropylethylamine (DIPEA). The yield is usually around 75-85%, and the reaction is selective and efficient.

N-(3-Chlorophenyl)-2-pyridinecarboxamide is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various pharmaceutical compounds and is also utilized in the production of organic materials like polymers and sensors. Its applications in semiconductors are less common but are explored in specialized research contexts.

When handling N-(3-Chlorophenyl)-2-pyridinecarboxamide, it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to vapors. Spills should be cleaned up immediately using appropriate methods, and the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) should be consulted for detailed safety information and emergency procedures. Storage should be done in a cool, dry place away from direct sunlight.