N-(3-Nitrophenyl)-3-oxobutanamide(CAS: 25233-49-2)

N-(3-Nitrophenyl)-3-oxobutanamide (CAS: 25233-49-2) is a white crystalline solid with a molecular weight of approximately 226.09 g/mol. It is poorly soluble in water but soluble in organic solvents such as methanol and acetonitrile. This compound is known for its reactivity, particularly towards nucleophiles, and can undergo reactions such as substitution and elimination.

N-(3-Nitrophenyl)-3-oxobutanamide is typically synthesized via the condensation of 3-oxobutanoyl chloride with 3-nitrophenol in the presence of a base like pyridine. The reaction is carried out under anhydrous conditions, and the product is isolated by crystallization from an appropriate solvent. The yield is generally good, around 70-85%.

N-(3-Nitrophenyl)-3-oxobutanamide (CAS: 25233-49-2) is used in various industries, including pharmaceuticals for its potential as a precursor in drug synthesis, and in polymers for its reactivity in functional polymerization. It is also used in the development of sensors and as a precursor in semiconductor materials for its unique functional groups.

When handling N-(3-Nitrophenyl)-3-oxobutanamide (CAS: 25233-49-2), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. This compound should be used in a fume hood due to its volatility and potential for airborne exposure. In case of spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.