5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS: 652148-93-1)

5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a crystalline compound with a molecular weight of approximately 321.05 g/mol. It has limited solubility in common organic solvents. The compound is known for its reactivity in Suzuki coupling reactions. It forms a stable solid at room temperature and is stable under normal conditions.

5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is typically synthesized through a boronation reaction of 5-chloropyridine with 4,4,5,5-tetramethyl-2-borono-1,3,2-dioxaborolane in the presence of a palladium catalyst and a base such as potassium carbonate. The reaction yields a pure product with high selectivity and good yield.

5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine finds applications in pharmaceutical and materials science industries. It is used as a key intermediate in the synthesis of complex organic molecules and as a boron source in organoboron chemistry for the preparation of functionalized boron-containing compounds.

When handling 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. The substance should be stored in a cool, dry place away from heat sources. Spills should be handled carefully, and the Material Safety Data Sheet (MSDS) should be consulted for specific instructions on proper disposal and emergency procedures.