3-Oxo-4-isoindolinecarbaldehyde(CAS: 771-08-4)

3-Oxo-4-isoindolinecarbaldehyde (CAS: 771-08-4) is a white crystalline solid with a molecular weight of approximately 164.21 g/mol. It is only slightly soluble in water but soluble in common organic solvents such as ethanol and acetone. The compound is reactive and prone to decomposition under basic conditions. It exhibits good reactivity towards nucleophiles and electrophiles, making it suitable for various chemical transformations.

3-Oxo-4-isoindolinecarbaldehyde is typically synthesized through the condensation of 4-isoindoline-1,3-dione with formaldehyde using an acid catalyst, such as hydrochloric acid or sulfuric acid. The reaction is carried out under reflux conditions, and the product is isolated by recrystallization from an appropriate solvent. The yield of the reaction is typically around 75-85%, with good selectivity to the desired product.

3-Oxo-4-isoindolinecarbaldehyde (CAS: 771-08-4) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving isoindoline scaffolds. It is also used in the polymer industry as a monomer for the production of certain types of polymers. Additionally, it finds applications in the production of sensors and semiconductors due to its reactive nature and ability to participate in various chemical reactions.

When handling 3-Oxo-4-isoindolinecarbaldehyde (CAS: 771-08-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye contact. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate tools and materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.