(R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one(CAS: 1383146-20-0)

(R)-4-(2,4-Dimethoxybenzyl)-3-methylpiperazin-2-one is a colorless to white crystalline solid with a molecular weight of approximately 320.35 g/mol. It has a moderate solubility in water and organic solvents like ethanol and methanol. This compound exhibits good stability under normal conditions but is susceptible to hydrolysis in the presence of strong acids or bases. It is also known for its reactivity in nucleophilic substitution reactions.

(R)-4-(2,4-Dimethoxybenzyl)-3-methylpiperazin-2-one is commonly synthesized via the condensation of 2,4-dimethoxybenzyl chloride with 3-methylpiperazine in the presence of a phase transfer catalyst like tetrabutylammonium bromide. The reaction provides a good yield (typically >90%) and excellent selectivity for the (R)-enantiomer.

(R)-4-(2,4-Dimethoxybenzyl)-3-methylpiperazin-2-one is used in the pharmaceutical industry for the synthesis of various drugs and intermediates due to its structural complexity and functional groups. It also finds applications in the polymer industry for modifying polymer properties and in the sensor and semiconductor industries for electronic applications.

When handling (R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of potentially toxic fumes. Spills should be cleaned up with care, using appropriate absorbents, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.