1-(4-Methoxyphenyl)guanidine(CAS: 67453-80-9)

1-(4-Methoxyphenyl)guanidine is a white crystalline solid with a molecular weight of approximately 188.18 g/mol. It has a solubility of about 400 mg/L in water. This compound is highly reactive, particularly with nucleophiles. It is stable under normal conditions but can decompose at high temperatures or under basic conditions.

1-(4-Methoxyphenyl)guanidine is commonly synthesized through the reaction of 4-methoxybenzylamine with carbodiimide in the presence of a base. This method provides good yield and selectivity. The reaction involves the formation of an amide linkage and the removal of a carbodiimide derivative as a byproduct.

1-(4-Methoxyphenyl)guanidine is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a stabilizer and in the development of sensors for detecting various chemicals. Additionally, it has applications in the semiconductor industry for specific purification processes.

When handling 1-(4-Methoxyphenyl)guanidine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials, and contaminated waste should be disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.