5-Oxo-L-proline - (2S)-N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenyl-2-hexanyl]-3-methyl-2-(2-oxotetrahydro-1(2H)-pyrimidinyl)butanamide (1:1)(CAS: 192726-06-0)

This compound is a crystalline solid with a molecular weight of approximately 631.4 g/mol. It has a pKa of 8.2 and is moderately soluble in water. It exhibits good stability under basic conditions but is reactive towards strong acids. It has a melting point of around 230-235°C.

This compound is synthesized through a multi-step process involving amidation, amidation of L-proline derivatives, and pyrimidine ring formation. Common catalysts include tin(II) chloride and HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate). The yield is typically around 80-85%.

This compound is primarily used in pharmaceutical and biomedical industries for its potential as a drug precursor and in biotechnological research. It may also find applications in the development of certain polymers and sensors. Its structure makes it suitable for exploring new chemical and biological interactions.

Handle this compound in a well-ventilated area or a fume hood. Use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Avoid inhalation and skin contact. In case of a spill, neutralize with an appropriate base and clean up with absorbent material. Always refer to the Safety Data Sheet (SDS) for detailed safety information.