2-Cyclopropyl-5-pyrimidinecarboxylic acid(CAS: 648423-79-4)

2-Cyclopropyl-5-pyrimidinecarboxylic acid is a white crystalline solid with a molecular weight of approximately 185.17 g/mol. It is slightly soluble in water and more soluble in common organic solvents. The compound exhibits good stability under normal conditions but is reactive towards strong bases and reducing agents.

2-Cyclopropyl-5-pyrimidinecarboxylic acid can be synthesized via the reaction of 5-bromopyrimidine and cyclopropylamine followed by an acid-catalyzed condensation. The reaction typically yields a mixture that requires purification by recrystallization or chromatography.

2-Cyclopropyl-5-pyrimidinecarboxylic acid is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds applications in the polymer industry for the development of functional polymers and in the production of certain sensors and semiconductors.

When handling 2-Cyclopropyl-5-pyrimidinecarboxylic acid, it is important to wear proper personal protective equipment (PPE), including gloves and safety glasses. The compound should be stored away from strong bases and reducing agents. In case of a spill, it should be cleaned up with care, following the safety data sheet (SDS) guidelines. Work should be conducted in a well-ventilated area or a fume hood to minimize the risk of inhalation exposure.