Cyclopamine(CAS: 4449-51-8)

Cyclopamine is a steroidal alkaloid compound with the chemical formula C22H41NO4. It is a white crystalline powder, insoluble in water but soluble in organic solvents. Naturally occurring in plants like Veratrum viride, Cyclopamine is known for its tetracyclic terpenoid structure and bioactive properties, including modulation of the Hedgehog signaling pathway.

Cyclopamine is primarily used in pharmaceutical research as a potent inhibitor of the Sonic Hedgehog (Shh) pathway, targeting cancer and developmental disorders. It also serves as a tool compound in biochemical studies and may have applications in veterinary medicine. Its unique structure makes it valuable for drug discovery and understanding cellular processes.

Cyclopamine is toxic if ingested or inhaled, requiring careful handling. Safety precautions include wearing gloves, goggles, and a lab coat, and working in a fume hood. While it is used in controlled research environments, exposure should be minimized. Always follow safety guidelines and regulatory standards for handling this compound.

Cyclopamine should be stored in a cool, dry, and dark place, preferably at 2-8°C, to maintain stability. It requires airtight containers to prevent moisture and contamination. Avoid exposure to light and incompatible substances. Proper storage ensures longevity and safety when handling this compound.