4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid(CAS: 89853-87-2)

4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid is a crystalline solid with a molecular weight of approximately 253.34 g/mol. It has a pKa of around 4.7 in aqueous solution and a solubility of about 1.5 g/L in water. The compound shows moderate reactivity, particularly towards nucleophiles and bases. It is prone to hydrolysis and nitration but resistant to oxidation.

4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid can be synthesized through a multi-step process involving the condensation of ethyl ethylthioacetate with 2-amino-4-chloropyrimidine, followed by reduction of the chloride group. The synthesis typically uses sodium borohydride as a reducing agent, yielding a product with a purify yield of about 75-80%. The reaction conditions should be optimized for maximum selectivity and yield.

4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. It also finds applications in the production of certain polymers and sensors due to its chemical reactivity and functional groups.

When handling 4-Amino-2-(ethylthio)pyrimidine-5-carboxylic acid, appropriate personal protective equipment (PPE) should be used, including safety goggles, gloves, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to prevent inhalation of dust or vapors. Spills should be cleaned up using appropriate absorbents and proper disposal methods. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.