(16alpha)-21-Chloro-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl 2-furoate(CAS: 83880-65-3)

(16alpha)-21-Chloro-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl 2-furoate is a white crystalline solid with a molecular weight of approximately 436.25 g/mol. It is slightly soluble in organic solvents like ethanol and dimethyl sulfoxide. Chemically, it is known for its stability under neutral conditions but can be reactive towards strong oxidizing agents. Its physicochemical properties are crucial for its application in pharmaceuticals and research.

(16alpha)-21-Chloro-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl 2-furoate is synthesized through a multi-step process involving alkene oxidation, chlorination, and esterification reactions. The synthesis typically requires careful control of temperature and the use of specific catalysts to achieve high yield and selectivity. This compound is often prepared using a combination of reagents such as tert-butyl hydroperoxide, sodium hypochlorite, and 2-furoic acid.

(16alpha)-21-Chloro-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl 2-furoate finds applications in the pharmaceutical industry due to its structural similarity to steroid hormones. It is also used in research for the development of new drugs and in the production of certain polymers. Additionally, it may be involved in the synthesis of other chemical intermediates and has potential uses in sensor technology and semiconductor manufacturing.

When handling (16alpha)-21-Chloro-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl 2-furoate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to prevent inhalation. If a spill occurs, it should be cleaned up immediately with caution, using appropriate spill containment materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.