6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine(CAS: 746668-59-7)

6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine is a solid with a crystalline form. Its molecular weight is approximately 243.04 g/mol. It has low solubility in water but is more soluble in organic solvents like DMF and DMSO. This compound is known for its high reactivity, particularly towards nucleophiles and electrophiles, making it suitable for various synthetic transformations.

6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine is often synthesized via a multi-step process involving the bromination of 5-methyl[1,2,4]triazolo[1,5-a]pyridine followed by amination of the resulting bromide. This synthesis typically requires the use of a catalytic amount of a Lewis acid and a base, yielding a product with a good yield and high selectivity.

6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds. It also finds applications in the polymer industry as a precursor for the development of advanced materials and in the semiconductor industry for doping purposes.

Handling 6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine should be done with caution. Always wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of the compound. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for further details on handling and disposal.